Enable FileVault. This is probably the simplest way to do it. Go to System Preferences’ Security & …

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Hide Outlook Data file in Navigation Pane - Microsoft

Hide My Files is an application which allows you to hide your private data. It is ideal the moment you share your computer with multiple users, since it grants you a certain level of security.

Wise Folder Hider - No.1 Freeware to Hide Folders or Files

Hide your files and folders from prying eyes. Set your master password and lock your files. No one can access your files without your master password. Hide Files supports NTFS, exFAT, FAT32 and FAT16 file system types, local hard drives, external hard drives, SSD drives, SD/MMC memory cards and USB flash disks.